As we delve into the fascinating world of microbiome research, it’s remarkable to reflect on how mass cytometry has expanded its reach from the realm of human cells, which we’ve explored extensively in previous chapters, to the complex ecosystems of microorganisms that inhabit our bodies. This chapter ties together concepts from our earlier discussions on immune profiling and environmental health, while introducing the unique challenges and opportunities presented by microbiome research.
Profiling Host-Microbiome Interactions
The groundbreaking work of Gury-BenAri et al. (2016) published in Cell demonstrated how the microbiome shapes the spectrum and regulatory landscape of intestinal innate lymphoid cells. Their use of mass cytometry to profile these interactions at high resolution opened new avenues for understanding the intricate dialogue between host and microbiome.
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