The intersection of cardiovascular disease and immunology might not seem obvious at first glance, but recent research has revealed a complex interplay between the immune system and heart health. Mass cytometry (CyTOF) has emerged as a powerful tool in unraveling this intricate relationship, offering new insights into atherosclerosis, heart failure, and myocardial infarction recovery.
Atherosclerosis and Plaque Composition
Atherosclerosis, once thought to be primarily a lipid storage disease, is now recognized as a chronic inflammatory condition. CyTOF has been instrumental in characterizing the diverse immune cell populations within atherosclerotic plaques.
Winkels et al. (2018) published a groundbreaking study cited over 465 times in Circulation Research, creating an atlas of immune cell repertoire in mouse atherosclerosis using single-cell RNA-sequencing and mass cytometry. This work revealed unprecedented detail in the composition of atherosclerotic plaques, identifying novel immune cell subsets potentially involved in disease progression.
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