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Dr. Guillaume Beyrend-Frizon - About & Publications

Dr. Guillaume Beyrend-Frizon

MD-PhD • Creator of Cytofast R Package • Editor at Frontiers in Immunology

Physician-scientist bridging cutting-edge immunotherapy research with practical educational tools. Creator of the Cytofast R package with 15 peer-reviewed publications in Cell Reports Medicine, JITC, and JoVE. Training 500+ scientists worldwide in advanced cytometry analysis through LearnCytometry.com.

🎯 Career Trajectory

2025 - Present
Physician in Switzerland
Swiss Healthcare System
Practicing physician focusing on developing innovative educational content for medical professionals. Combining clinical expertise with computational biology to advance precision medicine education.
2020 - 2025
Medical Doctor Candidate
Medical University
Completed medical training while developing LearnCytometry.com and publishing groundbreaking research in immunotherapy. Translated PhD research into practical clinical applications.
2016 - 2020
PhD in Tumor Immunology
Leiden University Medical Center (LUMC)
Conducted pioneering research in immunotherapy mechanisms, developed the Cytofast R package, and published seminal papers on checkpoint blockade and cytometry analysis. Created computational tools still used worldwide.
2013 - 2016
Research Scientist
UCB Pharma
Led drug discovery research projects focusing on immunological targets. Developed expertise in translational medicine and pharmaceutical research methodologies.
2012 - 2013
Research Scientist
Novartis
Early career pharmaceutical research experience, building foundation in drug development and clinical research methodologies.

🏆 Key Achievements

15+
Peer-Reviewed Publications
500+
Scientists Trained
1
R Package Created
5
Major Journal Publications

🎤 Speaking & Teaching Engagements

📚 Selected Publications

OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum
Beyrend G, van der Sluis TC, van der Gracht ETI, Abdelaal T, et al.
Cell Reports Medicine (2023) - Cited 17 times
PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors
Beyrend G, van der Gracht E, Yilmaz A, et al.
Journal for ImmunoTherapy of Cancer (JITC) (2019) - Cited 82 times
Cytofast: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations
Beyrend G, Stam K, Höllt T, Ossendorp F, Arens R
Computational and Structural Biotechnology Journal (2018) - Cited 60 times
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection
Wesselink TH, Behr FM, van Duikeren S, Beyrend G, et al.
Nature Communications (2022) - Cited 48 times
Memory CD8+ T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment
van der Gracht ETI, Beyrend G, Abdelaal T, Pardieck IN, et al.
iScience (2021) - Cited 9 times
Visualizing dynamic changes at the maternal-fetal interface throughout human pregnancy by mass cytometry
Van der Zwan A, Van Unen V, Beyrend G, et al.
Frontiers in Immunology (2020) - Cited 38 times
Identification of a disease-associated network of intestinal immune cells in treatment-naive inflammatory bowel disease
Kooy-Winkelaar Y, Abdelaal T, Beyrend G, et al.
Frontiers in Immunology (2022) - Cited 30 times
Cytomegalovirus infection and progressive differentiation of effector-memory T cells
Pardieck IN, Beyrend G, Redeker A, et al.
F1000Research (2018) - Cited 27 times
Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models
Moerland M, Feiss G, Beyrend G, et al.
Journal for ImmunoTherapy of Cancer (2020) - Cited 17 times
Spondyloarthritis mass cytometry immuno-monitoring: a proof of concept study in the tight-control and treat-to target TiCoSpA trial
Koppejan H, Beyrend G, Hameetman M, et al.
Clinical Rheumatology (2023) - Cited 1 time

PhD Thesis

Complete doctoral dissertation available for detailed review of research methodology and findings.

📖 Download PhD Thesis
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